Rettsyndrome.org Opens Call for Proposals in the following Programs: 

The Translational Research Program 

The Neuro-Habilitation Research Program

The Clinical Research Program

The Basic Research Program 

The Mentored Training Fellowship Program

 

Important Dates:   

The Translational Research Program , The Neuro-Habilitation Research Program and The Clinical Research Program

 

Letters of Intent due: May 25, 2018

Invitation of full applications sent by: June 6, 2018

Applications due: July 18, 2018

 

The Basic Research Program and The Mentored Training Fellowship Program

 

Letters of Intent due: May 25, 2018

Invitation of full applications sent by: June 6, 2018

Applications due: July 25, 2018

 

Details of the RFAs and Funding Mechanisms

Translational StudiesRequest for Applications

As we continue to look for drugs that can help correct the biology associated with Rett syndrome, we are in need of a screening system that can evaluate a large number of compounds quickly and efficiently.  Today we use the Scout Program to evaluate drug candidates but because the Scout Program is an in vivo model screen it is limited in the number of drugs we can screen in a year.  We would like to receive letters of intent that develop  an in vitro screen that can screen large libraries leading to families of molecules that could be moved into an in vivo screen.

 

Funding Mechanism:

  • The maximum funding for this HeART grant is $150,000 for two years ($75,000 per year).
  • Grants are made for technical support, supplies, equipment and relevant travel.  PI salary support may be included, but limited to 20% of the total award.
  • Indirect costs of up to 10% of direct costs may be included within the request amount.
  • Second year funding is non-competitive but is based on review of the first year’s progress reports.

 

Neuro-Habilitation and Clinical Studies – Request for Applications

  1. Communication challenges are issues that are one of the largest issues for families of those with a Rett syndrome child.  We request applications to improve communication.  The spectrum of opportunities in regard to communication is wide, and we will entertain letters of intent covering a wide variety of ideas.
  2. Research in healthcare delivery is needed.  One challenge with Rett syndrome is that not all families are close to recognized Rett clinics.  Best practices could be delivered via telemedicine technologies.  We are looking for applications that objectively measure the gain of function using new telemedicine technologies.  Therapies need to be published showing clinical benefit, to be used as evidence for insurance and pediatric/adult care access to services.

Funding Mechanism:

  • The maximum funding for this HeART grant is $150,000 for two years ($75,000 per year).
  • Grants are made for technical support, supplies, equipment and relevant travel.  PI salary support may be included, but limited to 20% of the total award.
  • Indirect costs of up to 10% of direct costs may be included within the request amount.
  • Second year funding is non-competitive but is based on review of the first year’s progress reports.

 

Clinical Research Program* – Request for Applications

*These applications will undergo a 2-Tier Review Process: (1) Standard initial RSO review, (2) NHS consortium review & feedback on both the science as well as the practicality of execution

  1. NHS Pilot Project Grants, with defined scope as small scale trials, facilitated through NHS Network sites.  Projects types may include:
    1. Outcome measures
    2. Biomarkers, including wearables and medical devices
    3. Behavioral or therapy interventions
    4. Pragmatic trials that may require a multi-disciplinary approach in methodology (e.g. a neurologist, PT and AAC specialist) where trial outcome aims to improve QOL.

Funding Mechanism:

  • The maximum funding for this Pilot grant is $50,000 for one year.
  • Grants are made for technical support, supplies, equipment and relevant travel.  PI salary support may be included, but limited to 20% of the total award.
  • Indirect costs of up to 10% of direct costs may be included within the request amount.
  • Second year funding is non-competitive but is based on review of the first year’s progress reports.
  • Budget will need to be worked out with participating NHS Network Clinic(s).

 

  1. Neuro-habilitation and translational studies that have been funded through the HeART mechanism and have published their results will now need to validate their results in other locations.  It is our intentions to have these validation studies carried out at the clinical sites associated with the Natural History Study.  We are looking for applications that will move initial positive observations from single labs/single investigators into a multi-site environment.  To participate in this venue, it is necessary for the original P.I. to establish a relationship with at least two of the Natural History sites to conduct the validation study.

 

Funding Mechanism:

  • The maximum funding for this HeART grant is $150,000 for two years ($75,000 per year).
  • Grants are made for technical support, supplies, equipment and relevant travel.  PI salary support may be included, but limited to 20% of the total award.
  • Indirect costs of up to 10% of direct costs may be included within the request amount.
  • Second year funding is non-competitive but is based on review of the first year’s progress reports.
  • Budget will need to be worked out with participating NHS Network Clinic(s).


 

Basic Research – Request for Applications

  1. Basic research studies that are discovery-based and aim to identify novel translational targets.  These will aim to determine the mechanism or black box at the synapse, glia, etc.  (feedback/feedforward mechanisms)
  2. Basic research studies that have a common link between basic and translational research programs.  For example, identify mechanism or molecular targets of successful drug(s) in clinical trials.
  3. Basic research studies that will identify genetic modifiers and novel targets.
  4. Basic research studies that investigate whether oxidative/cellular stress is a causal or secondary effect of Rett syndrome.

Funding Mechanism:

  • The maximum funding for this Regular Research grants is $150,000 for two years ($75,000 per year).
  • Grants are made for technical support, supplies, equipment and relevant travel.  PI salary support may be included, but limited to 20% of the total award.
  • Indirect costs of up to 10% of direct costs may be included within the request amount.
  • Second year funding is non-competitive but is based on review of the first year’s progress reports.

 

Mentored Training Fellowship – Request for Applications

Rettsyndrome.org announces the availability of Mentored Training Fellowships to support scientists early in their career to in both basic and clinical research in the field of Rett syndrome so that they become successful, independent basic research scientists and clinical investigators.  The two year Mentored Training fellowships are designed to assist post-doctoral and clinical scientist researcher in training to establish careers in fields relevant to Rett syndrome research.  The Fellowship applicant is considered the Principal Investigator (PI) for the application, and is required to identify a sponsoring mentor.

We encourage novel basic research programs for Mentored Training Fellowships within the following emphasis areas:

  • Understanding the role of MeCP2 during normal brain development
  • Characterizing the role of MeCP2, including MeCP2 target genes, in normal structure and function of the developing and adult nervous system
  • Determination of the relationship between patterns of expression of MeCP2, FoxG1, CDKL5, and related proteins in the nervous system and the neurologic and behavioral phenotypes of patients with RTT and/or related animal models
  • The investigation of neuronal abnormalities that result from MeCP2 dysfunction
  • The role of microglial and macroglial cells in development as it relates to RTT
  • Understanding mechanisms and systems leading to aberrant behavior in RTT

Funding Mechanism:

  • The maximum funding for Mentored Training Fellowships is $100,000 for two years ($50,000 per year).
  • Grants are made for PI salary support, technical support, supplies, equipment and relevant travel.
  • Indirect costs of up to 10% of direct costs may be included within the request amount.
  • Second year funding is non-competitive but is based on review of the first year’s progress reports.