Revive Therapeutics Announces Positive Study Results From Its Research Collaboration With Rettsyndrome.org

 

TORONTO, ONTARIO--(Marketwired - April 28, 2015) - Revive Therapeutics Ltd. ("Revive" or the "Company") (TSX VENTURE:RVV), a clinical-stage company focused on commercializing treatments for gout and orphan drug indications such as Cystinuria, Wilson disease and Rett syndrome, today announced positive study results of the Company's REV-003 (Tianeptine) from its research collaboration with Rettsyndrome.org for the potential treatment of Rett syndrome.

The purpose of the study was to run a behavioral battery of tests to screen and assess the potential for REV-003 for the therapeutic treatment of Rett syndrome in a mouse model under the Rettsyndrome.org Scout Program. The study results assessed body weight, grip strength, gait analysis, and neurologic and behavioral parameters. In the studies, REV-003 was well-tolerated and had no effects on body weight, improved motor coordination in the rotarod test, reduced clasping to almost normal levels, normalized prepulse inhibition of startle at the higher dose, and significantly improved gait features, in particular the positioning of the paws. Full results of the study, including replication and expansion to other functional domains, will soon be published. As part of the research collaboration, Revive supplied the drug to conduct the study, and all raw data, samples and specimens arising from the performance of this study remain properties of Revive. The study was performed by PsychoGenics Inc., funded and managed by Rettsyndrome.org.

"We are very pleased with the outcome from the study as it confirms the potential of REV-003 to treat multiple symptoms that are affected in patients with Rett syndrome," said Fabio Chianelli, Chief Executive Officer of Revive. "We are committed to developing therapeutic solutions for rare diseases, such as Rett syndrome, and we look forward to advancing our Rett syndrome program in collaboration with Rettsyndrome.org."

"These promising results further suggest the potential of REV-003 for the treatment of Rett syndrome," commented Steven Kaminsky, PhD, Chief Science Officer of Rettsyndrome.org. "At Rettsyndrome.org, we are truly committed to bringing new treatment strategies forward in hopes of improving the quality of life for those suffering with Rett syndrome. The success of this study paves the way for future clinical studies, and we look forward to continuing our relationship with Revive. We are hopeful that partnerships like this one will accelerate pre-clinical and clinical investigations in Rett syndrome. We are thankful to all who have contributed to Rettsyndrome.org to make the Scout Program possible."

About Rett Syndrome

Rett syndrome is a rare non-inherited genetic postnatal neurological disorder that occurs almost exclusively in girls and leads to lifelong impairments, affecting nearly every aspect of the child's life: their ability to speak, walk, and eat is affected, seizures develop and scoliosis occurs, and many develop irregular breathing patterns. Those diagnosed with Rett syndrome require maximum assistance with basic daily activities. The hallmark sign of Rett syndrome is near constant repetitive hand movements. Cognitive assessment in children with Rett syndrome is complicated, but they understand far more than they can communicate to us, evidenced by their bright and attentive eyes, and their ability to express a wide spectrum of moods and emotions.

About the Scout Program

Rettsyndrome.org aims to accelerate more discoveries to the clinic and committed over $600,000 towards the Scout Program, a Drug Discovery Screen in a mouse model of Rett syndrome. The Scout Program will aggressively accelerate the testing of compounds, whether new or repurposed, through standardized preclinical studies in the Rett mouse model. This program will test many novel compounds and small molecules through a contract with the CRO, PsychoGenics, Inc.

About Rettsyndrome.org

Rettsyndrome.org is the most comprehensive nonprofit organization dedicated to accelerating research of treatments and a cure for Rett syndrome and related disorders while providing information and family empowerment. As the world's leading private funder of Rett syndrome research, Rettsyndrome.org has funded over $35M in high-quality, peer-reviewed research grants and programs to date. The organization hosts the largest global gathering of Rett researchers and clinicians to establish research direction for the future. Rettsyndrome.org, a 501(c)3 organization, has earned Charity Navigator's most prestigious 4 star rating year after year. To learn more about our work and Rett syndrome, visit www.rettsyndrome.org or call (800) 818-7388 (RETT).

About PsychoGenics Inc.

PsychoGenics is a leader in vivo phenotypic drug discovery provider. The Company applies standard and proprietary technology platforms to in-licensed genetic mouse models in partnership with pharmaceutical and biotechnology companies, and foundations, to discover the next generation of drugs for neuropsychiatric and developmental disorders. For more information on PsychoGenics Inc. visit www.psychogenics.com.

About Revive Therapeutics Ltd.

Revive Therapeutics Ltd. (TSX VENTURE:RVV) is a clinical-stage company focused on commercializing treatments for gout, which is currently in a Phase II-A clinical study in the U.S., and orphan drug indications such as Cystinuria, Wilson disease and Rett syndrome. Additional information on Revive is available at www.revivethera.com.

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Although these assumptions were considered reasonable by management at the time of preparation, they may prove to be incorrect. Factors that may cause actual results to differ materially from those anticipated by these forward looking statements include: uncertainties associated with obtaining regulatory approval to perform clinical trials and market products; the need to establish additional corporate collaborations, distribution or licensing arrangements; the Company's ability to raise additional capital if and when necessary; intellectual property disputes; increased competition from pharmaceutical and biotechnology companies; changes in equity markets, inflation, and changes in exchange rates; and other factors as described in detail in Revive's Annual Information Form for the period ended June 30, 2014 and Revive's other public filings, all of which may be viewed on SEDAR (www.sedar.com). Given these risks and uncertainties, readers are cautioned not to place undue reliance on such forward looking statements and information, which are qualified in their entirety by this cautionary statement. Except as required by law, Revive disclaims any intention and assumes no obligation to update or revise any forward looking statements to reflect actual results, whether as a result of new information, future events, changes in assumptions, changes in factors affecting such forward looking statements or otherwise.

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