Completed Projects
IRSF has funded hundreds of successfully completed research projects. Many of these projects have informed our understanding of Rett, established researchers in the field, or directly impacted the treatments and cures advancing today.
Previously Funded Research
Meaningful research requires incremental progress and building upon prior discoveries. For decades, we have funded a wide spectrum of Rett and Rett-related research initiatives, including genetic approaches, fundamental biology, developing non-genetic approaches, clinical research, and more.
2021IRSF-Funded Research
2021
IRSF-Funded Research
Determine the role of loss of MECP2 in human Rett Brain
- William Lowry, PhD
- University of California, Los Angeles
This project is aimed at examining Rett brain samples to learn which types of neurons are most susceptible to the disease and whether the disease is caused by differences in the proportion of various neuronal subtypes. This study will not only point to novel therapeutic targets, but will also help determine which laboratory models most accurately approximate authentic Rett Syndrome.
Innovation Award, 2021
Mitochondrial Dynamics and Astrocyte Contribution to Development of RTT Pathophysiology in Human ESC-derived Cerebral Organoids
- Danielle Tomasello, PhD
- Whitehead Institute for Biomedical Research
This proposal aims to understand how when astrocytes – a type of cell found in the brain – carrying a MECP2 mutation influence brain organization and function. The approach employs mini-brains stimulated by gentle electrical pulses.
Mentored Training Fellowship, 2021
Human microglial cells as a therapeutic target in Rett Syndrome
- Pinar Mesci, PhD
- University of Calfornia, San Diego
Microglial cells are the resident immune cells of the brain. Adding healthy microglial cells onto Rett neurons improves their function, suggesting that microglial cells play an essential role in neuronal communication. This project tests several pharmacological drugs aiming to restore the microglial function, testing them in both cell cultures and Rett mouse models.
Innovation Award, 2021
A new view on Rett syndrome and its treatment through whole-brain functional connectomics in model mice
- Lieselot Carrette, PhD
- University of California, San Diego
This project aims to visualize whole-brain communication networks at single neuron scale to study abnormalities in Rett syndrome model mice, males and females, at different points in the disease progression.
innovation award, 2021
Exploring the contribution of transposable elements for the pathogenesis of Rett syndrome
- Anne-Valerie Gendrel, PhD
- Instituto de Medicina Molecular João Lobo Antunes
A large portion of our genome is made of repetitive elements that can self-propagate. In the human brain, their activity is believed to be important for neuronal plasticity; however, in Rett syndrome, some of these elements were shown to be over-active in neuronal cells. This project tests if this over-activity contributes to the disease process by employing a combination of cellular models, advanced genome engineering technologies, and bioinformatics.
Innovation Award, 2021
2020IRSF-Funded Research
2020
IRSF-Funded Research
Development of an in vivo human neuronal model for MECP2 related disorders
- Hilde Van Esch, MD, PhD
- Katholieke Universiteit Leuven
Most Rett syndrome research relies on animal models, which can limit insights into human brain mutations. This project utilizes patient-derived stem cells and transplants them into developing mouse brains to study brain development and behavior, hoping to gain insights for potential treatments.
Basic Research Award, 2020
In-silico optimized guideRNAs to revert monogenetic diseases by site-directed RNA editing
- Thorsten Stafforst, PhD
- University of Tübingen
Dr. Stafforst’s lab has developed a new way of performing gene-modifying therapy that utilizes RNA editing, a process that modifies the specific RNA intermediate made from a gene before it is used to make a functional protein product. This research will determine if the lab’s RNA editing technology can treat Rett syndrome.
Basic Research Award, 2020
Functional Analysis of an Enhancer-like Element Required for Xist Expression
- Evan Snyder, MD, PhD
- Sanford Burnham Prebys Medical Discovery Institute
Reactivating the silent X-chromosome may provide females with Rett syndrome the normal MeCP2 protein their cells need for proper functioning. This research explores a novel method of X-chromosome reactivation identified by Dr. Snyder’s lab.
Basic Research Award, 2020
Cellular and molecular drug screening system for Rett syndrome therapy
- Nicoletta Landsberger, PhD
- University of Milan
Drug screening methods in mouse models are time-consuming and costly. This proposal aims to develop a reproducible drug screening system using cell cultures from RTT mouse models. This approach will streamline the testing process and provide a more efficient way to identify potential treatments for clinical trials.
HeART-Translational Research Award, 2020
Pathophysiological structure, interactomics, and function of the N-terminus of MeCP2-E1 and its disease-related mutants
- Ferdinand Fiumara, MD, PhD
- University of Turin
Rett syndrome is caused by mutations in the MeCP2 protein, some of which are present in a part of the protein called the N-terminus. This research will determine if and how these mutations alter MeCP2 protein shape and how it interacts with other proteins.
Basic Research Award, 2020
Investigation of the therapeutic potential of a lead like mGluR7 activator for Rett syndrome
- Louise Dickson, PhD
- Cerevance
The mGluR7 glutamate receptor is a promising target for treating Rett syndrome, linked to the MECP2 protein. Research shows that modulating mGluR7 can improve symptoms in mouse models, like breathing and social deficits. While selective compounds have been developed, these studies will assess their effects on behavior and gene expression in treated mice, supporting mGluR7 as a potential therapeutic target for future clinical use.
HeART-Translational Research Award, 2020
Thalamo-cortical signaling in female Rett model mice
- Kerry Delaney, PhD
- University of Victoria
The brain cells of females with Rett syndrome are of mixed MeCP2 protein status (e.g. some cells have normal MeCP2 while others have a mutant MeCP2 that causes Rett syndrome). This research teases apart how this mixed MeCP2 status impacts communication among brain cells.
Basic Research Award, 2020
Investigating the role of microglia in Rett syndrome using multiple human cellular models
- Lotje de Witte, PhD
- Icahn School of Medicine at Mount Sinai
Microglia, the brain’s immune cells, play a key role in both inflammation and development. Research indicates their function is altered in Rett syndrome, impacting the disorder. This project is aimed at creating human microglia models from Rett patients’ cells to explore their role in the disease and test potential new treatments.
Basic Research Award, 2020
2019IRSF-Funded Research
2019
IRSF-Funded Research
Evaluation of AAV9-BDNF treatment in two mouse models of RTT
- Jean-Christophe Roux, PhD
- Aix Marseille University
Increased Bdnf expression can rescue certain deficits associated with MeCP2 deficiency in mice, which raises the possibility of using Bdnf as a therapeutic tool for Rett syndrome. This project will test this idea by evaluating the effect of AAV9-Bdnf treatment in two mouse models of RTT.
basic research Award, 2019
Drug Discovery Screen in a Mouse Model of Rett Syndrome
- Psychogenics Inc.
SCOUT Program Award, 2019
Can non-invasive interventions synergistically enhance the efficacy of MECP2 gene therapy?
- Sarah Sinnett, PhD
- University of North Carolina at Chapel Hill
Mentored Training Fellowship, 2019
Clinical characterization of MECP2 Duplication Syndrome and validation of a biomarker to prepare for therapeutic intervention
- Davut Pehlivan, MD
- Baylor College of Medicine
Mentored Training Fellowship, 2019
Reactivating the silent MECP2 allele through a synergistic drug mechanism
- Jeannie Lee, MD, PhD
- Massachusetts General Hospital
ANGEL-Translational Award, 2019
RTT Consortium Database Administration
- Jeffrey Krischer, PhD
- University of South Florida
Database Grant, 2019
RSBQ Characterization: Normative Reference Values and Factor Structure in Children and Adults
- Walter Kaufmann, MD
- Anavex Life Sciences
Clinical Research Award, 2019
2018IRSF-Funded Research
2018
IRSF-Funded Research
Drug Discovery Screen in a Mouse Model of Rett Syndrome
- Psychogenics Inc.
SCOUT Program Award, 2018
Understanding the Molecular Etiology of Rett Syndrome
- Zhaolan (Joe) Zhou, PhD
- University of Pennsylvania
Basic Research Award, 2018
Using wearable devices and ecological momentary assessment to define clinical severity in RTT
- Sarika Peters, PhD
- Vanderbilt University Medical Center
Clinical Research Award, 2018
The Impact of IL-6 on the interplay between neurons and astrocytes in Rett Syndrome
- Alysson Muotri, PhD
- University of Calfornia, San Diego
Basic Research Award, 2018
Restoration of Homeostasis of downstream targets of MeCP2 as a potential therapeutic of Rett Syndrome
- Jessica MacDonald, PhD
- Syracuse University
Basic Research Award, 2018
Individualized home based remote rehabilitation programs for individuals with Rett syndrome and their families
- Meir Lotan, PhD
- Ariel University
HeART Neuro-Habilitation Award, 2018
Effect of Positive Allosteric modulation of Dopamine D2 Receptors on Respiration in Mouse models of Rett Syndrome
- Erica Levitt, PhD
- University of Florida
Basic Research Award, 2018
Hyperactive GABAergic mutations and Rett syndrome
- Saad Hannan, PhD
- University College London
Mentored Training Fellowship, 2018
Characterizing Biomarkers of Epileptogenesis in Rett Syndrome
- Cary Fu, MD
- Vanderbilt University
Mentored Training Fellowship, 2018
Implementing telehealth support to increase physical activity in girls and women with Rett syndrome
- Jenny Downs, PhD
- University of Western Australia
Neuro-Habilitation Award, 2018
Painless NGF: testing the rescue of Rett syndrome neuronal degeneration through its actions on microglia
- Antonino Cattaneo, PhD
- Scuola Normale Superiore
Translational Research Award, 2018
Behavioral Disorders in Rett Syndrome
- Carrie Buchanan, MD
- Greenwood Genetic Center
Mentored Training Fellowship, 2018
2017IRSF-Funded Research
2017
IRSF-Funded Research
Identification of biomarkers of IGF1’s related drugs in Rett syndrome
- Daniela Tropea, PhD
- Trinity College Dublin
This project analyzes blood samples from Rett syndrome patients treated with trofinetide in phase 2 clinical trials and their relative clinical information to identify the molecular markers present in responders to the drug.
translation research award, 2017
Drug Discovery Screen in a Mouse Model of Rett Syndrome
- Psychogenics Inc.
SCOUT Program Award, 2017
Transgenic T. gondii as a platform for MeCP2 protein delivery to the CNS
- Lilach Sheiner, PhD
- University of Glasgow
Basic Research Award, 2017
Cognitive Outcome Measures for Rett Syndrome: Assessment of Reliability and Stability
- Susan Rose, PhD
- Albert Einstein College of Medicine
Neuro-Habilitation Award, 2017
Exploring nonsense suppression as a treatment for Rett syndrome
- Lucas Pozzo-Miller, PhD
- University of Alabama-Birmingham
Translational Research Award, 2017
Tailoring gene replacement therapy for MECP2-related disorders
- Colleen Niswender, PhD
- Vanderbilt University
Basic Research Award, 2017
Exploration of metabotropic glutamate receptor 3 as a target for MeCP2-related disorders
- Colleen Niswender, PhD
- Vanderbilt University
Basic Research Award, 2017
Wearable Sensors for Multifunctional Assessment in Rett Syndrome
- Eric Marsh, MD, PhD
- Children's Hospital of Philadelphia
Translational Research Award, 2017
Reactivating the silent MECP2 allele through a synergistic drug mechanism
- Jeannie Lee, MD, PhD
- Massachusetts General Hospital
Translational Research Award, 2017
Cortical inhibitory mechanism governing auditory perception in MeCP2+/-
- Billy Lau, PhD
- University of Tennessee at Knoxville
Mentored Training Fellowship, 2017
Towards identifying therapeutic targets of MECP2 deficiency
- Nicholas Katsanis, PhD
- Duke University
Translational Research Award, 2017
Testing potential regulators of BDNF expression to identify candidate Rett syndrome therapeutics
- Kevin Jones, PhD
- University of Colorado, Boulder
Basic Research Award, 2017
Programmable transcription of MeCP2 in patient iPSC-derived neurons using CRISPR/dCas9 as a putative therapeutic for Rett Syndrome
- Kyle Fink, PhD
- University of Calfornia, Davis
Basic Research Award, 2017
Two-photon imaging of excitatory/inhibitory cortical activity in mosaic Mecp2 female animal model
- Michela Fagiolini, PhD
- Boston Children's Hospital, Harvard Medical School
Basic Research Award, 2017
Improving Upper Extremity Motor Skills in Children with RTT Using Selected Movements to Control Internet Virtual Reality Computer Games
- Pamela Diener, PhD, MS, OT/L
- Georgetown University
Neuro-Habilitation Award, 2017
In Vitro and In Vivo Validation of Candidate Drugs to Treat Rett Syndrome
- Qiang Chang, PhD
- University of Wisconsin-Madison
Translational Research Award, 2017
2016IRSF-Funded Research
2016
IRSF-Funded Research
Trofinetide Phase 2 Pediatric Trial
- Neuren Pharmaceuticals
Contract - Clinical Trials, 2016
A Phase 2b placebo-controlled crossover study of rhIGF1 (mecasermin [DNA] injection) for treatment of Rett syndrome and development of Rett-specific novel biomarkers of cortical and autonomic function.
- Mustafa Sahin, MD
- Boston Children’s Hospital
Angel Awards - Clinical Trials, 2016
The InterRett database: achieving international breadth and longitudinal depth in Rett syndrome
- Helen Leonard, MBChB, MPH
- Telethon Kids Institute
Database Grant, 2016
Randomized, Double-Blind, Placebo-Controlled, Dose-Titration of ANAVEX 2-73 in Patients with Rett Syndrome
- Daniel Klamer, PhD
- Anavex Life Sciences
Angel Awards - Clinical Trials, 2016
Drug Discovery Screen in a Mouse Model of Rett Syndrome
- Taleen Hanania, PhD
- Psychogenics Inc.
SCOUT Program Award, 2016
RettBASE: IRSF MECP2 Variation Database – a Global Resource
- John Christodoulou, AM
- Children’s Hospital at Westmead
Database Grant, 2016
2015IRSF-Funded Research
2015
IRSF-Funded Research
A Phase 2 clinical trial of trofinetide, also known as NNZ-2566, for females with Rett Syndrome ages 5-15
- Neuren Pharmaceuticals
Clinical Trial Funding, 2015
A Phase 2b placebo-controlled cross-over study of rh-IGF1 (mecasermin [DNA] injection) for treatment of Rett syndrome and development of Rett-specific novel biomarkers of cortical and autonomic function
- Mustafa Sahin, MD
- Boston Children's Hospital
Clinical Trial Funding, 2015
Identification of Impairments in Attention Associated with Rett Syndrome
- Susan Rose, PhD
- Albert Einstein College of Medicine
HeART-Neuro-Habilitation Award, 2015
Investigating the Molecular Mechanisms of MeCP2 Isoform-Specific Regulation in Brain Cells
- Mojgan Rastegar, PhD
- University of Manitoba
Basic Research Award, 2015
Role of mTOR pathway in the pathogenesis of Rett syndrome
- Sampathkumar Rangasamy, PhD
- Translational Genomics Research Institute
Basic Research Award, 2015
UCSD Integrated Read-through Program for Rett Syndrome
- Jeffrey Neul, MD, PhD
- University of California, San Diego
Angel Awards - Read-Through Program, 2015
Characterization of the Gut Microbiome and Metabolome in Rett Syndrome
- Kathleen Motil, MD, PhD
- Baylor College of Medicine
Heart Award, 2015
Exosome-mediated cell-cell communication in Rett Syndrome
- Pinar Mesci, PhD
- University of California, San Diego
Mentored Training Fellowship, 2015
Targeting IL-1-mediated inflammation and associated dysbiosis to treat Rett syndrome
- John Lukens, PhD
- University of Virginia
Basic Research Award, 2015
Synaptic mechanisms and novel therapeutic strategies for Rett Syndrome
- Keji Li, PhD
- Massachusetts Institute of Technology
Mentored Training Fellowship, 2015
Reversing speech sound processing deficits in Rett syndrome
- Michael Kilgard, PhD
- University of Texas at Dallas
Heart Award, 2015
Evaluation of a Novel Therapeutic Intervention to Improve Motor Function in Rett Syndrome
- Seth Hays, PhD
- University of Texas at Dallas
Heart Award, 2015
Understanding microglia diversity and IGF signaling in Rett Syndrome
- Timothy Hammond, PhD
- Boston Children’s Hospital, Harvard
Mentored Training Fellowship, 2015
Investigating TRPM2 As A Therapeutic Target For Rett Syndrome
- James Eubanks, PhD
- University Health Network
Basic Research Award, 2015
Characterizing and evaluating movement disorders and understanding structural and functional network abnormalities in Rett Syndrome
- Marisela Dy, MD
- Boston Children’s Hospital
Mentored Training Fellowship, 2015
An evaluation of environmental enrichment for young girls with Rett syndrome
- Jenny Downs, PhD
- Telethon Kids Institute
HeART-Neuro-Habilitation Award, 2015
Development of Clinical Guidelines for the Management of Communication in Individuals with Rett Syndrome
- Leopfold Curfs, PhD
- Maastricht University
Heart Award, 2015
Scout Program: A Drug Discovery Screen in a Mouse Model of Rett Syndrome
- Daniela Brunner, PhD
- PsychoGenics Inc.
SCOUT Program Award, 2015
2014IRSF-Funded Research
2014
IRSF-Funded Research
Molecular Mechanisms of Homeostatic Synaptic Plasticity in Mecp2 KO Neurons
- Xin Xu, PhD
- The University of Alabama at Birmingham
Mentored Training Fellowship, 2014
Characterization of a Novel Activity-Dependent Phosphorylation Site on MECP2
- William Renthal, MD, PhD
- Harvard Medical School
Mentored Training Fellowship, 2014
Inhibitory interneuron dysfunction in network activity in female Mecp2 mice
- Lucas Pozzo-Miller, PhD
- The University of Alabama at Birmingham
Basic Research Award, 2014
Analogs of (1-3)IGF-1 (glypromate) for the improvement of hippocampal dysfunction in female Mecp2 heterozygous mice: a preclinical trial for Rett syndrome
- Lucas Pozzo-Miller, PhD
- The University of Alabama at Birmingham
Heart Award - SCOUT Program, 2014
Auditory processing, language, and learning in Rett and Rett-related disorders
- Sarika Peters, PhD
- Vanderbilt University Medical Center
HeART-Neuro-Habilitation Award, 2014
NLX-101 – a novel, highly selective and potent serotonergic 5-HT1A receptor agonist for the treatment of respiratory arrhythmias in Rett Syndrome: a pre-clinical proof-of-principle study in murine models
- Julian Paton, PhD
- University of Bristol
Angel Award, 2014
New Methods to Assess Cognition and Affect in Girls with Rett Syndrome
- Charles Nelson, III, PhD
- Boston Children's Hospital
HeART-Neuro-Habilitation Award, 2014
Effects of NMDA receptor modulators on network activity in a human iPSC-derived model of cortical dysfunction in Rett Syndrome
- Frank Menniti, PhD
- Mnemosyne Pharmaceuticals, Inc.
Heart Award, 2014
InterRETT
- Helen Leonard, MBChB, MPH
- The University of Western Australia
Database Contract, 2014
Targeting Protein Degradation Pathways to Treat RTT
- Janine Lamonica, PhD
- University of Pennsylvania
Mentored Training Fellowship, 2014
Investigating Visual Attention to Print in Children with Rett Syndrome
- David Koppenhaver, PhD
- Appalachian State University
HeART-Neuro-Habilitation Award, 2014
Immune pathology and bone marrow transplantation in disorders of MeCP2 overexpression
- Jonathan Kipnis, PhD
- University of Virginia
Basic Research Award, 2014
A Phase 2b placebo-controlled cross-over study of rh-IGF1 (mecasermin [DNA] injection) for treatment of Rett syndrome and development of Rett-specific novel biomarkers of cortical and autonomic function
- Walter Kaufmann, MD
- Boston Children's Hospital
Supplemental funding to current project, 2014
Brain Delivery of BDNF via novel Nano-formulation for Treatment of Rett Syndrome
- Alexander Kabanov, PhD
- University of North Carolina at Chapel Hill
Heart Award, 2014
Consequences of altered DNA Methylation/hydroxymethylation caused by the loss of MeCP2 in neurons
- Peng Jin, PhD
- Emory University
Basic Research Award, 2014
Sensory Neural Network Alterations in Rett Syndrome
- Darren Goffin, PhD
- Unversity of York
Basic Research Award, 2014
A randomized, double-blind placebo controlled trial of NNZ-2566 (IGF-1{1-3}, glycyl-L-2-methylprolyl-L-glutamine acid) with open label extension in adults with Rett syndrome
- Daniel Glaze, MD
- Baylor College of Medicine
Supplemental funding to current project, 2014
Restoring the AKT/mTOR pathway to Treat Rett syndrome
- Maurizio Giustetto, PhD
- University of Torino, Italy
Heart Award - SCOUT Program, 2014
Drug Therapy Targeted to Core Molecules in Neural Plasticity Cascades: A Promising Tool for the CDKL5 Variant of Rett Syndrome
- Claudia Fuchs, PhD
- University of Bologna, Italy
Mentored Training Fellowship, 2014
Assessing NMDAr modulators to ameliorate cortical regression in Rett Syndrome
- Michela Fagiolini, PhD
- Boston Children's Hospital
Heart Award, 2014
Improving Upper Extremity Motor Skills in Children with RTT Using Selected Movements to Control Internet Virtual Reality Computer Games
- Pamela Diener, PhD
- Marymount University
HeART-Neuro-Habilitation Award, 2014
Preclinical evaluation of the bacterial protein CNF1 as a novel therapeutic approach for Rett syndrome
- Bianca De Filippis, PhD
- Istituto Superiore di Sanita, Italy
Heart Award - SCOUT Program, 2014
RettBASE
- John Christodoulou, AM
- Sydney Children’s Hospital Network, Australia
Database Contract, 2014
Assessing oculomotor function in Rett syndrome using integrated EEG and eye tracking technology
- Breanne Byiers, PhD
- University of Minnesota
Mentored Training Fellowship, 2014
Scout Program: A Drug Discovery Screen in a Mouse Model of Rett Syndrome
- Daniela Brunner, PhD
- PsychoGenics Inc.
Supplemental funding to current project, 2014
Rett Syndrome Rat Model Working Group
- Daniela Brunner, PhD
- PsychoGenics Inc.
New Research Program, 2014
Sensory Integration to Increase Functional Reaching in Children with Rett syndrome and related disorders
- Susan Bruce, PhD
- Boston College
HeART-Neuro-Habilitation Award, 2014
A biophysical basis for cellular and developmental regulation by MeCP2
- Michael Brenowitz, PhD
- Albert Einstein College of Medicine
Basic Research Award, 2014
2013IRSF-Funded Research
2013
IRSF-Funded Research
Post-transcriptional control of MECP2 expression during human development and disease
- ,
- The Hospital For Sick Children, Toronto
Basic Research Award, 2013
Restoring network integration of MeCP2-deficient neurons
- Xinyu Zhao, PhD
- University of Wisconsin-Madison
Basic Research Award, 2013
Neurophysiology of cortical neurons in heterozygous female Rett mouse brain
- Felipe Santos de Oliveira, PhD
- University of Victoria
Basic Research Award, 2013
Treating Rett syndrome via selective reactivation of the silenced MECP2 allele
- Jeannie Lee, MD, PhD
- Massachusetts General Hospital
HeART Award, 2013
A Phase 2b placebo-controlled cross-over study of rh-IGF1 (mecasermin [DNA] injection) for treatment of Rett syndrome and development of Rett-specific novel biomarkers of cortical and autonomic function
- Walter Kaufmann, MD
- Children’s Hospital Boston
Supplemental funding to current project, 2013
BDNF gene transfer for the treatment of Rett syndrome
- Steven Gray, PhD
- University of North Carolina at Chapel Hill
HeART Award, 2013
Temporal divergence of hypoconnectivity and excitotoxicity in Rett syndrome
- Rocco Gogliotti, PhD
- Vanderbilt University Medical Center
Basic Research Award, 2013
Role of IGF1R in hippocampal CA2 plasticity and function: interaction with MeCP2
- Serena Dudek, PhD
- National Institute of Environmental Health Sciences
Basic Research Award, 2013
Imaging dynamics of cortical neuron dendritic spines in female heterozygous Rett mouse brain
- Kerry Delaney, PhD
- University of Victoria
Basic Research Award, 2013
Preclinical Evaluation of Tubastatin A, a Novel Therapy for Rett Syndrome
- John Christodoulou, AM
- The Children's Hospital at Westmead
HeART Award, 2013
Eyetracking in Rett syndrome: A preliminary investigation of receptive and expressive vocabulary
- Theresa Bartolotta, PhD
- Seton Hall University
HeART Award, 2013
2012IRSF-Funded Research
2012
IRSF-Funded Research
Testing potential regulators of BDNF expression to identify candidate Rett syndrome therapeutics
- Kevin Jones, PhD
- University of Colorado, Boulder
HeART-Translational Research Award, 2012
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