SMART Initiative

The SMART Library Now Available for Research

 

The SMART (Selected Molecular Agents for Rett Therapy) library of compounds is well vetted by modern day bioinformatics methods, tightly focused on Rett syndrome and its biological causes. The library is currently housed at the University of Illinois-Chicago where it is administered by Dr. Kozikowski and Dr. Gaisina. 

The Rettsyndrome.org Science Advisory Board has also recommended a number of compounds that have been either purchased or prepared and are now included in the library. With the goals in mind to save both time and resources and accelerate drug discovery for Rett syndrome, the compounds in the SMART library will be readily available to investigators working on Rett syndrome research.
Click here for a Summary of the SMART library or contact Dr. Janice Ascano at

jascano@rettsyndrome.org and Dr. Irina Gaisina at UIC (igaysina@uic.edu).

For researchers who wish to obtain compounds, please fill out this application form and email Dr. Janice Ascano at jascano@rettsyndrome.org

Some Examples of the Drugs from SMART Library

TargetClassDrug/Compound
BDNF Antidepressants
(SSRIs; SNRIs; NaSSAs, NRI, NDDI; MAOIs; TCAs)
Citalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertaline; Duloxetine, Milnacipran; Mianserin, Mirtazapine; Atomoxetine, Reboxetine; Pirlindole, Agomelatine; Oclobemide, 3,4-Difluoro benzocurcumin, Isocarboxazide; Amitriptyline, Doxepin, Desipramine, Maprotiline;
BDNF mimetics LM22A-3, LM22A-4
TrkB Ampakines; Cyclothiazide, CX-546, CX-614, IDRA-21, GYKI-52466, GYKI-53655, Fanapanel, Perampanel;
TrkB agonists 7,8-Dihydroxyflavone, Aniracetam, Tianeptine
IGF1 Growth hormone secretagogues Tabimoreline, MK-677
  IGF1 potentiators NBI-31772
GABA GABA modulators; Theanine, Chlormezanone, Topiramate;
analogs; Gabapentin;
receptor agonists; Gaboxadol, Acamprosate, Baclofen;
reuptake inhibitors Tiagabine
GSK3 LiCl, small molecule GSK3 inhibitors: maleimides, thiadiazolidones, indirubins, paullones AR-A014418, SB 216763, ING-135, TDZD, BIO
PKA Antipsychotics Risperidone, Ziprasidone, Asenapine, Aripiprazole
HDAC Inhibitors (carboxylates; hydroxamic acids; benzamides) SAHA, Sodium phenylbutyrate, TSA, CI994, Oxamflatin, Tubastatin A
Methyltransferase Inhibitors (HKMT, DNA) BIX-01294, RG 108
Carbonic anhydrase Anhydrase inhibitors Acetazolamide, Methazolamide, Dorzolamide, Topiramate
NMDA Antagnists; Lamotrigine;
AChEI Ambenonium, Rivastigmine, Huperzine A