Laboratory Resources
Animal Models - facilities that provide Mecp2 mouse strain breeding services for use in scientific research.
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Other Resources for Novel Animal Generation
Tissue & Cell Collections
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Brain Tissue Resources
- The Harvard Brain Tissue Resource Center (HBTRC) has fresh frozen and formalin fixed tissues of brain samples from over Rett brains banked by International Rett Syndrome Foundation. All tissue requests for samples from Rett syndrome brain donors will be sent to IRSF for approval. For more information, please call HBTRC directly at 1-800-272-4622 or contact Dr. Dominique Pichard, IRSF Chief Science Officer at [email protected].
- The University of Maryland Brain and Tissue Bank
- Coriell Cell Repository
- National Human Neural Stem Cell Resource (NHNSCR)
Rett Research Databases
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- ClinVar – a freely accessible, public archive of reports of human variations classified for diseases and drug responses, with supporting evidence. It contains the most up-to-date information on the status of specific gene changes in the MECP2, FOXG1, and CDKL5 genes, including data from RettBASE that has been assessed against ACMG classification criteria and transferred.
- InterRett – an international online database examining the clinical features and genetic characteristics of Rett syndrome.
- RettBASE – a freely accessible database that was initially established over 20 years ago through funding support from IRSF, the NSW Rett Syndrome Association, and the Rett Syndrome Association of Australia (RSAA). RettBASE was established to capture MECP2 gene changes in individuals with a clinical diagnosis of Rett syndrome, that came from the published research literature or through direct submissions by clinicians or laboratories. Although the RettBASE link is live for now, it is no longer being updated, and we recommend that ClinVar should be used to obtain the most up to date information about the status of specific gene changes in MECP2. In addition, as the Rett syndrome community transitions to using ClinVar, to meet interim requests for submission of information relating to specific MECP2 gene changes into RettBASE, an online form has been created (web form link). This link will be accepting submissions through the end of 2024. For questions, please contact Dr. Nupur Garg at [email protected].