Grant Programs Overview

Translational Research Grant Program 

“To develop treatments that change the biology of Rett Syndrome”

HeART (Help Accelerate RTT Therapeutics) grant awards are designed to promote the development and testing of therapeutics to treat and reverse Rett syndrome (RTT).  Awards will be provided for cell-based assay development, early-stage drug discovery and development, early stage medicinal chemistry efforts on high value candidate therapeutics, cell-based screening of candidate therapeutics and follow-on early-stage in vivo testing. Grant applications for exploratory studies towards development of biomarkers or objective clinical outcome measures will also be considered. The goal of this award mechanism is to provide seed funding for early stage drug discovery and development efforts.

We encourage novel research programs that broadly encompass the following areas of unmet need:

  • Design, synthesis and testing of potential disease modifying therapeutics to treat or reverse RTT
  • Testing of existing therapeutics both in vitro and in vivo to repurpose their use in RTT
  • Development and/or validation of in vitro and in vivo models of RTT for therapeutic testing
  • Development and/or validation of novel biomarkers for objective clinical trials outcome measures
  • Testing of IND-ready therapeutics in pilot clinical trials

Funding:

  • The maximum funding for HeART awards is $150,000 for two years ($75,000 per year).
  • Grants are made for technical support, supplies, equipment and relevant travel.  PI salary support may be included, but limited to 20% of the total award.
  • Indirect costs of up to 10% of direct costs may be included within the request amount.
  • Second year funding is non-competitive but is based on review of the first year’s progress report.

ANGEL (Advanced Neurotherapeutic Grant of Excellence) grant awards must be comprised of very specific programs that are focused on pre-clinical drug discovery and development or clinical testing of therapeutic candidates. The goal is to provide larger, multi-year awards with a strong emphasis placed on the later stages of translational research. ANGEL awards will be milestone-based and as such are subject to interim review of progress.

Funding:

  • The maximum funding for ANGEL awards is $600,000 for two years ($300,000 per year).
  • Grants are made for technical support, supplies, equipment and relevant travel.  PI salary support may be included, but limited to 20% of the total award.
  • Indirect costs of up to 10% of direct costs may be included within the request amount.
  • Second year funding is non-competitive but is based on review of the first year’s progress report.

Basic Research Grant Program

“To correct the biology we first must understand what has gone wrong”

Rettsyndrome.org announces the availability of Regular Research grants for international biomedical research to promote the understanding of MeCP2 in the pathogenesis of the neurobehavioral phenotype of Rett syndrome (RTT). We seek to gain a better understanding of the underlying pathology of the disorder leading to an amelioration of the symptoms and a cure for RTT.  The two year Regular research grant awards are meant to (1) provide seed money for research that encompasses innovative therapeutic approaches and cutting-edge diagnostic techniques, (2) design to assist investigators establish careers in fields relevant to Rett syndrome research, and (3) lead to follow-on funding from other agencies.

Funding:

  • The maximum funding for this Regular Research grants is $150,000 for two years ($75,000 per year).
  • Grants are made for technical support, supplies, equipment and relevant travel.  PI salary support may be included, but limited to 20% of the total award.
  • Indirect costs of up to 10% of direct costs may be included within the request amount.
  • Second year funding is non-competitive but is based on review of the first year’s progress reports.

Mentored Training Fellowship Program

“To build the lab bench of future Rett syndrome researchers”

Rettsyndrome.org announces the availability of Mentored Training Fellowships to support scientists early in their career to in both basic and clinical research in the field of Rett syndrome so that they become successful, independent basic research scientists and clinical investigators.  The two year Mentored Training fellowships are designed to assist post-doctoral and clinical scientist researcher in training to establish careers in fields relevant to Rett syndrome research.  The Fellowship applicant is considered the Principal Investigator (PI) for the application, and is required to identify a sponsoring mentor.

Funding:

  • The maximum funding for Mentored Training Fellowships is $100,000 for two years ($50,000 per year).
  • Grants are made for PI salary support, technical support, supplies, equipment and relevant travel.
  • Indirect costs of up to 10% of direct costs may be included within the request amount.
  • Second year funding is non-competitive but is based on review of the first year’s progress reports.

We encourage novel basic research programs for Regular Research Grants and Mentored Training Fellowships within the following emphasis areas:

  • Understanding the role of MeCP2 during normal brain development
  • Characterizing the role of MeCP2, including MeCP2 target genes, in normal structure and function of the developing and adult nervous system
  • Determination of the relationship between patterns of expression of MeCP2, FoxG1, CDKL5, and related proteins in the nervous system and the neurologic and behavioral phenotypes of patients with RTT and/or related animal models
  • The investigation of neuronal abnormalities that result from MeCP2 dysfunction
  • The role of microglial and macroglial cells in development as it relates to RTT
  • Understanding mechanisms and systems leading to aberrant behavior in RTT

Neuro-Habilitation Research Grant Program

“To reset the neurology we must find methods to habilitate cognition, speech, occupational and physical activities”

Neuro-Habilitation HeART (Help Accelerate RTT Therapeutics) grant awards are designed to provide funding for research aimed at maximizing function and abilities in the boys and girls with Rett syndrome. The program specificcaly targets research for cognitive therapies, physical therapies, occupational therapies and speech therapies, which  will directly impact the quality of life for those affected by Rett syndrome.

Funding:

  • The maximum funding for HeART awards is $150,000 for two years ($75,000 per year).
  • Grants are made for technical support, supplies, equipment and relevant travel.  PI salary support may be included, but limited to 20% of the total award.
  • Indirect costs of up to 10% of direct costs may be included within the request amount.
  • Second year funding is non-competitive but is based on review of the first year’s progress report.

Find more information on how to apply.

Click here to view open calls for proposals.