Awards & Grants Opportunities

Research into a variety of Rett and Rett-related topics is necessary to create treatments and cures for every individual living with Rett syndrome.

IRSF proudly invest in research at every stage: from basic science that can change the way we think about MeCP2 to clinical research that directly impacts potential treatments. We also help connect Rett researchers with external funding opportunities.

Scroll down to learn more about the research funding opportunities available thanks to IRSF supporters who donate, advocate, and raise awareness for Rett syndrome.

IRSF Funding Opportunities

IRSF has invested more than $58M towards accelerating research advancements toward both treatments and a cure for Rett syndrome. With support from our generous donors, we are proud to provide funding regularly through a variety of grant mechanisms.


2024 Rett Syndrome Innovation Awards

Grant Cycle Opens April 15, 2024

The Rett Syndrome Innovation Awards seek to advance research aimed at investigating the underlying pathology of the disorder and identifying novel therapeutic approaches to treat and cure Rett syndrome. The program aims to (1) provide seed money for innovative research that leads to the identification of therapeutic targets or approaches to treat Rett syndrome, (2) assist investigators to establish careers in the field of Rett syndrome research, and (3) lead to follow-on funding from other agencies. IRSF is grateful to all our donors whose generous support drives our research funding program.

Funding Level:
Up to $300,000 total for two years (up to $150,000 per year)

Letter of Intent – Due May 15, 2024
Full Proposal (by invitation) – Due July 7, 2024


EXTERNAL Funding Opportunities

IRSF advocates for external funding to support the researchers broadening our understanding of Rett syndrome and translating their findings to real-world treatments.

U.S. Department of Defense Peer Reviewed Medical Research Program (PRMRP) Awards

Fiscal Year 2024

The U.S. Department of Defense (DoD) recently announced its Fiscal Year 2024 (FY24) research funding awards through the Congressionally Directed Medical Research Program (CDMRP) / Peer Reviewed Medical Research Program (PRMRP). IRSF and its supporters have successfully advocated that Congress include Rett syndrome as a topic eligible for PRMRP funding in FY24, resulting in the following federal opportunities:

Clinical Trial Award (CTA)

  • Preproposal Due: May 13
  • Full Application Due: August 19

Discovery Award (DA)

  • Letter of Intent Due: May 6
  • Full Application Due: May 23

Investigator-Initiated Award (IIRA)

  • Letter of Intent Due: May 6
  • Full Application Due: May 23

Impact Award (IPA)

  • Letter of Intent Due: May 13
  • Full Application Due: June 6

Lifestyle and Behavioral Health Interventions Research Award (LBIRA)

  • Letter of Intent Due: May 13
  • Full Application Due: June 6

Technology/Therapeutic Development Award (TTDA)

  • Letter of Intent Due: May 13
  • Full Application Due: June 6


DoD Application Support

Created for the FY22 award cycle, watch the video below to learn more about creating a successful DoD application for PRMRP Funding. Contact [email protected] to have your CTA or FPA reviewed by IRSF’s DoD representative prior to submission.