Rare Disease Day

Rett syndrome is rare – but hope doesn’t have to be.

Join IRSF this Rare Disease Day to help raise awareness of Rett syndrome and fund our critical mission to accelerate research and empower families living with Rett all over the world.


We are grateful to Dave & Kevin (Raising a Hand for Rett) who continue to support our critical work this Rare Disease Day. On February 28th, they will generously match every dollar donated or fundraised – up to $50,000! That means that when you give – either personally or through an online fundraiser – every dollar you donate goes twice as far to create a world without Rett!



Raise Awareness

Your story is powerful. Share what living with Rett syndrome means for you and help make a difference in the lives of all individuals and families affected by Rett.

Fundraise for a cure

IRSF is relentlessly pursuing a cure for Rett syndrome in the future while also providing unwavering support for families fighting Rett right now. In ways big and small, you can help us fund this critical mission.

Together, let’s go ALL IN and make sure no family faces Rett syndrome alone.


As we relentlessly pursue a cure, we come alongside families with support, wherever they are on the journey. Each of them faces constant challenges, heartache, and disappointments. They all need compassionate and practical support, effective treatments, and ultimately, a cure.

You can meet those needs by helping us take incredible strides forward in much-needed research – this Rare Disease Day and beyond.

Let’s go ALL IN. For a cure. For families. For individuals with Rett, all over the world.

Go ALL IN to end Rett syndrome

About IRSF: The International Rett Syndrome Foundation (IRSF) is the leading research and family empowerment organization for Rett syndrome. We’re on a mission to transform the lives of all those affected by Rett syndrome by accelerating research toward treatment and a cure while empowering families with the information, programs, and services they need to thrive.

Over nearly 40 years, IRSF has invested more than $58 million to fund breakthrough discoveries and life-changing advancements in research while supporting thousands of individuals and families around the world at all stages in their Rett journey.

IRSF is a 501(c)(3) tax-exempt organization. More than 90% of every donor dollar is devoted to our mission.