Application Process

General Submission Guidelines

Considering the interdisciplinary nature of both Basic and Translational Research projects, collaborative studies among geneticists, molecular biologists, neuroscientists, child neurologists, medicinal chemists and pharmacologists engaged in drug discovery and other clinical or basic researchers are encouraged. Teams working together from different institutions as well as within pharmaceutical and biotechnology industries are strongly encouraged.

Grants are made for technical support, supplies, equipment and relevant travel. For HeART and Regular Research Grant mechanisms, PI salary support will now be considered on a case-by-case basis and may be limited to 20% of the total award. Indirect costs of up to 10% of direct costs may be included with the request amount. Proposals for less than the maximum amount are encouraged. Second year funding for all awards is non-competitive but is based on review of the first year’s progress report.

Eligibility accepts qualified, scientific proposals from academic institutions, existing, private, early-stage pharmaceutical and biotechnology industries (if a clear need for non-profit funding to support the project is demonstrated and justified) and other non-profit organizations worldwide. Investigators with “Research Associate” as their title are eligible to apply for mentored training fellowships only. Exceptions may be considered on a case by case basis.

The Two-Step Grant Application Process

Step One: Submit a Letter of Intent or Expression of Interest

The investigator must submit a Letter of Intent (LOI) through our website describing the project in a succinct manner. The LOI should include objectives and specific aims of the proposal, research design and methods, qualifications of the Principal Investigator, mentor (if applicable) and other principal investigators involved in the project. Preliminary data must be included within the page limitations. LOIs for the HeART, Regular Research Grants, and Mentored Training Fellowships should not exceed two pages. LOIs for the ANGEL grant mechanism should not exceed three pages.


  • requires all applicants to use our online submission process.
  • We have recently changed our grants management database, and you will need to create a new applicant account.
  • Principle Investigators will need to submit a copy of their CV in the following format.
  • Mentored Training Fellowship applicants must include a copy of their CV and that of their mentor in the following format.
  • You will need your institution’s Tax ID number to begin. If you do not have one, you may use your telephone number.

 Submit a Letter of Intent

Step Two: Complete and submit the electronic application form

After review of the LOI, we will contact the investigator via email to invite or decline a full proposal. Successful applicants will be provided with specific instructions to login, download, complete and submit the electronic application form.

Your application will be reviewed by members of the Scientific Review Board (SRB) for scientific merit, by and its internal Research Advisory Committee for programmatic review, and finally by the IRSF Board of Directors who will make the final funding decision.

For application submission inquiries, please contact:
Janice Ascano, Ph.D. Manager of Grants and Research - | 615-283-5943

For program related inquiries, please contact:
Steve Kaminsky, Ph.D., Chief Science Officer - | 301-514-4068

Deadline dates to be determined for the 2015 Basic Research Program and Mentored Training Fellowship.  Please check back for future announcements and click here to subscribe to the Research eNewsletter.