June 25 - 27, 2007
Eaglewood Resort & Spa
Itasca, IL
Co-chairs: Huda Zoghbi & Gail Mandel
Agenda
Monday, June 25
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5:00 pm
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Cocktail Reception
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6:00 pm
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Dinner
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7:40 pm
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Omar Khwaja
Children's Hospital Boston Clinical presentation |
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8:30 pm
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Discussion
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Tuesday, June 26
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7:00 am
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Breakfast
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8:00 am
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Intro to Session 1: MeCP2, Synapses, Network, and Behavior
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8:15 am
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Bruce McEwen
Rockefeller University Protective and damaging effects of mediators of stress and adaptation: Implications for Rett Syndrome |
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8:40 am
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Andrew Bauerschmidt
Johns Hopkins University MeCP2 deficiency in mice results in altered connectivity between the central nucleus of the amygdala and the ventrolateral nucleus of the solitary tract |
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9:05 am
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Christian Rosenmund
Baylor College of Medicine MeCP2 levels controls synapse formation in glutamatergic neurons |
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9:30 am
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Stephen Smith
Stanford University School of Medicine Array tomography and single-synapse analysis: new tools for the investigation of normal and disordered neural circuits in human and animal model brain tissues |
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9:55 am
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Break
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10:30 am
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Andrew Pieper
University of Texas Southwestern Medical Center In vivo identification of neurogenic small molecules for treatment of schizophrenia as a proposed model for the development of novel therapeutic agents for Rett Syndrome. |
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10:55 am
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Mark Bear
Massachusetts Institute of Technology, HHMI From gene to pathophysiology to treatment in fragile X |
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11:20 am
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Discussion
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Noon
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Lunch
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1:30 pm
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Intro to Session 2: MeCP2 Targets
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1:50 pm
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Sacha Nelson
Brandeis University Cell type specific alterations in gene expression in Mecp2 mutant mice |
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2:10 pm
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Gus Frangou
Fred Hutchinson Cancer Research Center A novel mammalian cell system to manipulate and analyze epigenetic gene regulation in vivo |
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2:35 pm
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Uta Francke
Stanford University School of Medicine Debunking an imprinting myth: DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency |
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3:00 pm
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Discussion facilitated by Marisa Bartolomei and Hunt Willard
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4:00 pm
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Free time
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5:00 pm
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Poster Session / Cocktails
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7:00 pm
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Dinner / Drinks
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Wednesday, June 27
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7:00 am
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Breakfast
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9:00 am
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Intro to Session 3: MeCP2 role in neurons and glia
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9:15 am
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Matthew Klein
Vollum Institute, Oregon Health & Science University Homeostatic regulation of MeCP2 by a CREB-regulated microRNA |
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9:40 am
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Zhaolan (Joe) Zhou
Children's Hospital, Harvard Medical School A role of neuronal activity-dependent phosphorylation of MeCP2 in brain |
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10:05 am
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Gail Mandel
Vollum Institute, Oregon Health & Science University MeCP2 is present in glia: is this a factor in Rett Syndrome? |
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10: 30 am
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Yi Sun
University of California Los Angeles The function of MeCP2 in human ES cell-derived neurons |
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10:55 am
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Break
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11:30 am
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Discussion
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12:30 pm
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Lunch and Departure
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7th Annual Rett Syndrome Symposium
June 26-28, 2006
Eaglewood Resort & Spa
Chicago, IL
Co-chairs: Huda Zoghbi & Gail Mandel
Agenda
Monday, June 26
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5:00 pm
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Cocktail Reception
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6:00 pm
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Dinner
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7:40 pm
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Monica Coenraads, Director of Research, RSRF
Introductory Remarks |
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7:45 pm
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Sarojini Budden, Oregon Health and Sciences University
Larry Swanson, University of Southern California Keynote Talk: Clinical Features and Neuroanatomy of Rett Syndrome |
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8:30 pm
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Poster Session A
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Tuesday, June 27
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7:00 am
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Breakfast
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8:00 am
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Yves Alain Barde, University of Basel
Brain-derived neurotrophic factor: quantification, distribution and role in the Nervous system of the mouse |
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8:30 am
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David Katz, Case Western University
BDNF and respiratory dysfunction in MeCP2 null mice |
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8:50 am
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Qiang Chang, Whitehead Institute
The role of neuronal activity induced MeCP2 phosphorylation - an in vivo study |
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9:10 am
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Yi Sun, University of California Los Angeles
MeCP2 phosphorylation and glycosylation the "Ying & Yang" aspects of MeCP2 post-translational modifications |
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9:30 am
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Dag Yasui, University of California Davis
Moonlighting Functions of MeCP2 Revealed by Identification of Novel Co-factors |
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9:50 am
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Break
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10:15 am
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Daniel Feldman, University of California San Diego
Rodent somatosensory cortex: A model system for understanding synapse maturation and plasticity |
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10:45 am
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Alicia Degano, Johns Hopkins University
Defects in Axonal Guidance In A Mouse Model Of Rett Syndrome |
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11:05 am
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Jean Charles Viemari, University of Chicago
Mechanisms underlying irregular breathing in Rett Syndrome |
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11:25 am
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Mark Bear, Massachusetts Institute of Technology
Keynote Talk: From neurobiology to therapy in fragile X |
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12:00 pm
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Lunch
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1:30 pm
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Late Breaking News
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1:50 pm
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Rusty Gage, Salk Institute
To be announced |
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2:20 pm
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Late Breaking News
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2:40 pm
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Discussion Led by Chairs
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4:00 pm
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Free Time
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5:30 pm
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Cocktail Reception
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6:30 pm
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Dinner
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8:00 pm
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Poster Session B
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Wednesday, June 28
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7:00 am
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Breakfast
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8:00 am
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Elly Nedivi, Massachusetts Institute of Technology
Dynamic structural rearrangement of dendritic arbors in non-pyramidal neurons of the cerebral cortex |
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8:30 am
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Noriyuki Kishi, Massachusetts General Hospital, Harvard Medical School
Identification and analysis of MeCP2 target genes in developing cerebral cortex projection neurons |
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8:50 am
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Jack Feldman, University of California Los Angeles
Looking For Inspiration: New Perspectives On Basic Mechanisms For Breathing |
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9:20 am
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Holly Cukier, Baylor College of Medicine
Using Drosophila to Investigate MeCP2 Function and Interactions |
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9:40 am
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John Rubenstein, University of California San Francisco
Role of the Dlx genes in differentiation of forebrain GABAergic neurons |
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10:10 am
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Break
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10:30 am
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Ramin Shiekhattar, University of Pennsylvania To be announced |
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11:00 am
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Gregory Pelka, Children's Hospital Westmead
Investigation of the impact of regionalized Mecp2 deficiency and the manifestation of the RTT phenotype using chimera analysis |
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11:20 am
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Nicoletta Landsberger, University of L'Insubria
Functional Characterization of CDKL5, a novel gene involved in the onset of Rett Syndrome |
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11:40 am
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Discussion led by Chairs
(Focus: Are we ready for translating basic science insights into interventions?) |
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12:45
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Lunch and Departure
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6th Annual Rett Syndrome Symposium
June 27 - 29, 2005
Eaglewood Resort & Spa
Chicago, IL
Co-chairs: Huda Zoghbi & Adrian Bird
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Monday, June 27
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 |
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5:00 pm
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Cocktail Hour
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6:00 pm
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Dinner
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7:30 pm
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Monica Coenraads, Director of Research, RSRF - Introductory Remarks
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7:45 pm
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Daniel Glaze, Baylor College of Medicine - Rett Syndrome: Opportunities for Understanding Neurodevelopmental Disorders
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8:30 pm
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Richard Goodman, Vollum Institute - Genome-wide screening for transcription factor binding sites
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Tuesday, June 28
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7:30 am
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Breakfast
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8:30
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Art Beaudet, Baylor College of Medicine - A mixed epigenetic and genetic and mixed de novo and inherited model for autism
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9:00
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Reiko Fitzsimonds, Yale University - Hippocampal Synaptic Plasticity is Impaired in the Mecp2-null Mouse Model of Rett Syndrome
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9:20
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Huda Zoghbi, Baylor College of Medicine, Howard Hughes Medical Institute - Synaptic dysfunction in a mouse model of Rett syndrome
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9:50
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Ulrike Nuber, Max Planck Institute for Molecular Genetics - Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome
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10:10
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Bruce Cohen, Cleveland Clinic - Mitochondria Dysfunction in Rett Syndrome: Is Rett Syndrome a Mitochondrial Disease?
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10:40
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Break
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11:10
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Peter Scheiffele, Columbia University - Function of Neuroligin Family Proteins at Neuronal Synapses
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11:40
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Jean-Christophe Roux, INSERM - Mecp2-deficiency disrupts norepinephrine and respiratory systems in mice: Implications for Rett Syndrome
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12:00
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John Greer, University of Alberta - Developmental Studies of Respiratory Rhythmogenesis in Rodent Models
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12:30 pm
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Lunch
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2:00
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Nathaniel Heintz, Rockefeller University, HHMI - Transcriptional Profiling of Defined CNS Cell Populations in BACarray Transgenic Mice
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2:30
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Juan Young, Centro de Estudios Cientificos - Exploring Novel functions for MeCP2
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2:50
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Discussion Led by Huda Zoghbi, Baylor College of Medicine, Howard Hughes Medical Institute
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4:00
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Poster Session/Cocktail Reception
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7:00
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Dinner
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Wednesday, June 29
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7:00 am
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Breakfast
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8:00
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Joe Zhou, Harvard University, Children's Hospital Boston - Neuronal activity-dependent phosphorylation of MeCP2
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8:30
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Qiang Chang, Whitehead Institute - Overexpression of BDNF in the Postnatal Brain Delays the Onset of RTT-like Symptoms in the Mecp2 Mutant Mice.
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8:50
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Helen Scharfman, Columbia University, Helen Hayes Hospital - Effects of acute and chronic BDNF overexpression in rats and mice and their implications for the etiology of Rett Syndrome.
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9:10
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Skirmantas Kriaucionis, University of Edinburgh - MeCP2 is responsible for recruitment of ATRX to heterochromatic foci in mouse brain
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9:30
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Weidong Wang, National Institute on Aging/NIH (some slides from Adrian) - MeCP2 is Regulated by Phosphorylation and Does Not Stably Associate with SWI/SNF Chromatin-Remodeling Complexes
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9:50
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Break
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10:20
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Pavel Belichenko, Stanford University - Dendritic Alterations in the Brains of Mouse Models of Rett Syndrome
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10:40
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Gregory Pelka, Sydney University, Children's Hospital Westmead - Insights into Rett syndrome pathophysiology through mouse models
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11:00
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Xinyu Zhao, University of New Mexico School of Medicine - Function of MeCP2 in postnatal neurogenesis and neuronal maturation
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11:20
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Discussion led by Adrian Bird, University of Edinburgh
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12:30 pm
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Lunch and Departure
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5th Annual Rett Syndrome Symposium
June 28 - 30, 2004
Inn at The Colonnade
Baltimore, MD
Co-Chairs: Huda Zoghbi & Adrian Bird
Monday, June 28
5:00 PM Cocktail Hour
6:00 PM Dinner
7:30 PM Monica Coenraads, Director of Research, RSRF
Introductory Remarks
7:45 PM Jeffrey Neul, Baylor College of Medicine
Rett Syndrome: What Can the Girls Teach the Scientist?
8:30 PM Michael Greenberg, Children's Hospital Boston, Harvard Medical School
MeCP2 as a Repressor of Activity-Dependent Gene Regulation
Tuesday, June 29
7:30 AM Breakfast
8:30 AM Yi Sun, UCLA
DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation
9:00 AM Ken-ichiro Kosai, Kurume University
Adenoviral MeCP2 Gene Therapy Partially Improves Neurological Symptoms of Rett Syndrome in Mice
9:20 AM Lisa Monteggia, UT Southwestern Medical Center
Behavioral Characterization of Conditional MeCP2 Knockout Mice
9:40 AM Michael G. Rosenfeld, UCSD, Howard Hughes Medical Institute
Genomic Patterns of Transcription and Coregulatory Factors in Integration of Biological Responses
10:10 AM Skirmantas Kriaucionis, University of Edinburgh
Gene expression analysis in MeCP2-null mice using a variant of differential display
10:30 AM Break
11:00 AM Brian Hendrich, University of Edinburgh
Identification of a role for methyl-CpG binding proteins in mammalian development
11:20 AM David Amaral, UC Davis, M.I.N.D. Institute
The Amygdala and Autism
11:50 AM Laura Herzing, Northwestern University
Concurrence of MeCP2-Mediated Decrease in Expression of the Angelman Syndrome Gene, UBE3A, between Rett Syndrome Patients and the Mecp2-knockout Mouse at an Actual, Rather than Developmental, Time-Frame
12:10 PM John Christodoulou, Children's Hospital at Westmead
12:30 PM Lunch
2:00 PM Luca Santarelli, Columbia University
Influence of postnatal hippocampal development and neurogenesis on anxiety and depression.
2:30 PM Gail Mandel, Stonybrook, Howard Hughes Institute
Regulation of neuronal phenotype by transcriptional repression
3:00 PM Discussion Led by Huda Zoghbi, Baylor College of Medicine, Howard Hughes Medical Institute
4:00 - 7:00 PM Poster Session/Cocktail Reception
7:00 - 8:30 PM Dinner
Wednesday, June 30
7:00 AM Breakfast
8:00 AM Gabrielle Ronnett, Johns Hopkins University
The Olfactory System as a Model for Rett Syndrome
8:30 AM Denis Jugloff, University of Toronto
Increased Dendritic Complexity and Axonal Length In Cultured Mouse Cortical Neurons Over- Expressing Methyl DNA Binding Factor MeCP2.
8:50 AM Nino Ramirez, University of Chicago
Is a lack of excitatory neuromodulators responsible for erratic breathing in Rett Syndrome?
9:10 AM En Li, Novartis
Genetic Study of DNMT3A and MECP2 Function in the Brain
9:40 AM Eva Gak, Tel Aviv University
Identification of Novel and Known MECP2 Mutations Employing Quantitative RNA Expression Studies in Peripheral Blood: Implications for the Rett Syndrome Phenotype
9:50 AM Break
10:30 AM Carl Wu, National Cancer Institute, NIH
Controlling Gene Expression by ATP-Driven Mobilization of Nucleosomes
11:00 AM Megumi Adachi, The Neurosciences Institute
DNA Elements That Regulate The MeCP2 Gene Promoter In Neuronal Cells
11:20 AM Discussion led by Adrian Bird, University of Edinburgh
12:30 AM Lunch and Departure
Child Neurology Society 33rd Annual Meeting
Ottawa, Ontario, Canada
October 13, 2004
Monica Coenraads, RSRF Co-founder and Director of Research, has been invited to participate in the Child Neurology Society Symposium on Rett Syndrome.
NIH/NINDS Symposium: Rett Syndrome
Moderator: Bernard L. Maria, MD, MBA, Executive Director of the ChildrenÍs Research Institute, Associate Director of the Neuroscience Institute, Jeffrey Edwin Gilliam Chair for Neurodevelopmental Disorders, Professor of Pediatrics, Neurology, Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina
7:30 AM - 7:35 AM
Introduction and Statement of Symposium Goals
Bernard L. Maria, MD, MBA
7:35 AM - 10:00 AM
CLINICAL ISSUES
Moderator: Alan K. Percy, M.D.
University of Alabama at Birmingham
Birmingham, Alabama
7:35 AM - 7:55 AM
RS: The Model of a Neurodevelopmental Disorder
Alan K. Percy, M.D.
7:55 AM - 8:25 AM
Clinical Profiles with Age - Classical Forms
Professor Bengt Hagberg
University of Goteborg
Goteborg, Sweden
8:25 AM - 8:50 AM
Clinical Profiles - Variant Forms
Ola Skjeldal
University of Oslo
Oslo, Norway
8:50 AM - 9:15 AM
Molecular Diagnosis of Rett Syndrome
Peter Huppke, M.D.
Georg-August-Universitat Gottingen
Gottingen, Germany
9:15 AM - 9:45 AM
Molecular Biology of MECP2
Huda Zoghbi, M.D.
Baylor College of Medicine
Houston, Texas
9:45 AM - 10:00 AM
Additional Question and Answer Sessions
10:00 AM - 10:15 AM
BREAK
10:15 AM - 12:30 PM
CLINICAL AND BASIC NEUROBIOLOGY
Moderator: Carolyn Schanen, M.D., Ph.D.
The Nemours Institute, A.I. Dupont
Wilmington, Delaware
10:15 AM - 10:45 AM
Clinical Neurophysiology
Daniel G. Glaze, M.D.
Baylor College of Medicine
Houston, Texas
10:45 AM - 11:15 AM
Neuropathology
Dawna D. Armstrong, M.D.
Baylor College of Medicine
Houston, Texas
11:15 AM - 11:45 AM
Neural Networks
Jeffrey D. Macklis, M.D., Ph.D.
Harvard Medical School
Boston, Massachusetts
11:45 AM - 12:15 PM
Implications for Neural Development
Michael V. Johnston, M.D.
Kennedy Krieger Institute
Johns Hopkins University School of Medicine
Baltimore, Maryland
12:15 PM - 12:30 PM
Additional Question and Answer Session
12:30 PM - 1:30 PM
Lunch
1:30 PM - 3:15 PM
CLINICAL PROGRESS
Moderator: Folker Hanefeld, M.D.
Georg-August-Universitat Gottingen
Gottingen, Germany
1:30 PM - 2:00 PM
Natural History with Age
Yoshiko Nomura
Segawa Neurological Clinic for Children
Tokyo, Japan
2:00 PM - 2:30 PM
Phenotype-Genotype Correlations
Carolyn Schanen, M.D., Ph.D.
The Nemours Institute, A.I. Dupont
Wilmington, Delaware
2:30 PM - 3:00 PM
Newborn Screening/Implications for Therapy
Ignatia B. van den Veyver, M.D.
Baylor College of Medicine
Houston, Texas
3:00 PM - 3:15 PM
Break
3:30 PM - 5:00 PM
FUTURE DIRECTIONS
Moderator: Masaya Segawa, M.D., Ph.D.
Segawa Neurological Clinic for Children
Tokyo, Japan
3:30 PM - 4:00 PM
Neurodevelopmental Disorders
Thomas Insel, M.D.
National Institute of Mental Health
Bethesda, Maryland
4:00 PM - 4:55 PM
Panel
Laura A. Mamounas, Ph.D.,
Program Director, Neurogenetics Cluster, NINDS, NIH
Monica Coenraads, Director of Research
Rett Syndrome Research Foundation
Lisa Forman, Ph.D., Scientific Director
International Rett Syndrome Association
Kathy Hunter, Founder and President,
International Rett Syndrome Association
4:00 PM - 5:00 PM
Closing Comments
Bernard L. Maria, M.D., MBA
