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Translational Research Program
IRSF announces the availability of HeART (Help Accelerate RTT Therapeutics) and ANGEL (Advanced Neurotherapeutic Grant of Excellence) grant awards to promote the development and testing of therapeutics to treat and reverse Rett syndrome (RTT) and its symptoms. These award mechanisms seek to facilitate the development and testing of novel therapeutics targeting the underlying pathology of the disorder, thereby leading to an amelioration of symptoms or ultimately a pharmacological reversal of RTT. Through these awards, IRSF seeks to foster academic and public-private partnerships and further facilitate drug discovery, development and testing. IRSF encourages novel research programs that broadly encompass the following areas of unmet need:
HeART (Help Accelerate RTT Therapeutics) Grant Award Goal: To provide seed funding for early stage drug discovery and development efforts. Funding: The maximum funding level for HeART grant awards is $50,000 for one year. HeART grant awards are provided for cell-based assay development, early-stage drug discovery and development, early stage medicinal chemistry efforts on high value candidate therapeutics, cell-based screening of candidate therapeutics and follow-on early-stage in vivo testing. Grant applications for exploratory studies towards development of biomarkers or objective clinical outcome measures will also be considered. Applications require a 3 page proposal narrative. ANGEL (Advanced Neurotherapeutic Grant of Excellence) Grant Award Goal: To provide funding for the later stages of translational research. Funding: The maximum funding level for ANGEL grant awards is $300,000 per year for up to two years. Proposals must be comprised of very specific programs focused on pre-clinical drug discovery and development or clinical testing of therapeutic candidates. This mechanism requires development of a milestone based research plan, interim reporting on milestones and interaction with IRSF staff prior to and during the award period. The budget and duration of funding are variable and continued funding will be based on satisfactory progress on milestones. Applications are usually solicited, however, unsolicited proposals will be considered. Preliminary inquiries are required to determine IRSF’s level of interest prior to submission of an Expression of Interest (EOI). Applications require a 10 page proposal narrative.
Basic Research Grant Program IRSF announces the availability of Regular Research grants and Post-doctoral Fellowships for international biomedical research to promote the understanding of MeCP2 in the pathogenesis of the neurobehavioral phenotype of Rett syndrome (RTT). We seek to gain a better understanding of the underlying pathology of the disorder leading to an amelioration of the symptoms and a cure for RTT. IRSF seeks to encourage research that encompasses innovative therapeutic approaches and state of the art diagnostic techniques. IRSF encourages applications within the following emphasis areas:
The two-year Post-doctoral Fellowships are designed to assist post-doctoral researchers establish careers in fields relevant to Rett Syndrome research. The maximum funding level for Post-doctoral Fellowships is $100,000 over two years. Post-doctoral Fellowship applicants are required to have a sponsoring mentor.
General Submission Guidelines Considering the interdisciplinary nature of both Basic and Translational Research projects, collaborative studies among geneticists, molecular biologists, neuroscientists, child neurologists, medicinal chemists and pharmacologists engaged in drug discovery and other clinical or basic researchers are encouraged. Teams working together from different institutions as well as within pharmaceutical and biotechnology industries are strongly encouraged. Grants are made for technical support, supplies, equipment and relevant travel. Indirect costs of up to 10% of direct costs may be included with the request amount. Proposals for less than the maximum amount are encouraged. Second year funding for Regular Research Grants, Post-doctoral Fellowships and ANGEL awards is non-competitive but is based on review of the first year’s progress report. The IRSF Two-Step Grant Application Process
IRSF accepts qualified, scientific proposals from Academic Institutions, existing, private, early-stage pharmaceutical and biotechnology industries (if a clear need for non-profit funding to support the project is demonstrated and justified) and other Non-Profit organizations worldwide. Investigators with “Research Associate” as their title are eligible to apply for post-doctoral fellowships only. Exceptions may be considered on a case by case basis. Please Note: IRSF requires all applicants to use our online submission process. We have recently changed our grants management database, and you will need to create a new applicant account. You will need your institution’s Tax ID number to begin. Follow the link below to begin this process. Submit Letter of Intent or Expression of Interest View Application Instructions For application submission inquiries, please contact: Janice Ascano, Ph.D. Manager of Grants and Research - This e-mail address is being protected from spam bots, you need JavaScript enabled to view it | 917-267-4504 For program related inquiries, please contact: Steve Kaminsky, Ph.D., Chief Scientific Officer - This e-mail address is being protected from spam bots, you need JavaScript enabled to view it | 917-267-4504
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Research Overview |